One study compar-ing FDG-PET with HMPAO SPECT in distinguishing AD(n= 20), nonAD dementias (n= 12), and cognitively normalelderly found a 90% diagnostic accuracy with FDG-PETand 67% accuracy using SPECT

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One study compar-ing FDG-PET with HMPAO SPECT in distinguishing AD(n= 20), nonAD dementias (n= 12), and cognitively normalelderly found a 90% diagnostic accuracy with FDG-PETand 67% accuracy using SPECT. This diagram illustratesthe interaction between type II collagen fibrils and type IX collagenmolecules in the cartilaginous matrix

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This diagram illustratesthe interaction between type II collagen fibrils and type IX collagenmolecules in the cartilaginous matrix. Activity of paraoxonase (PON), enzyme with antioxidant potential actingin the prevention of oxidation of LDL cholesterol, was significantly decreased in diabeticpatients compared to healthy controls however no significant difference was found in PONgene polymorphisms in relation of T1D and diabetic complications (Ikeda et al., 1998).According to another study, paraoxonase-1 activity and myeloperoxidase activity (as a markerof inflammation) were significantly increased and total antioxidant capacity was significantlydecreased in T1D patients compared to healthy controls

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Activity of paraoxonase (PON), enzyme with antioxidant potential actingin the prevention of oxidation of LDL cholesterol, was significantly decreased in diabeticpatients compared to healthy controls however no significant difference was found in PONgene polymorphisms in relation of T1D and diabetic complications (Ikeda et al., 1998).According to another study, paraoxonase-1 activity and myeloperoxidase activity (as a markerof inflammation) were significantly increased and total antioxidant capacity was significantlydecreased in T1D patients compared to healthy controls. Trials for prodro-mal AD will undoubtedly require different inclusion crite-ria, more follow-up time, and possibly different outcomemeasures than those classically used in mild-to-moderateAD trials (Aisen et al., 2011). Car-diovascular changes include hypertension, tachycardia, arrhythmias, and increasedoxygen requirements

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