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A large proportion of the missense mutations are associatedwith gain of function activities and arise in the ‘hotspot’ residues, of p53: R175,G245, R248, R273, R249 and R282. (2009) Postural changesin blood pressure and the prevalence of orthostatic hypotensionamong home-dwelling elderly aged 75 years or older. Alteration in the ribosomal bind-ing site for erythromycin by a plasmid encodedmethylase enzyme is an important mechanism ofresistance in gram-positive bacteria. A uniquepentasaccharide segment of the heparin molecule will bind toendogenous antithrombin. What are the restrictive and obstructive airway diseases? What are the differences?A. With a threshold at 30 mm/h (ESR) and at 10 mg/l (CRP), the sensitivities are91–97%, and the specificities 70–78% [29, 70, 71].
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